Regulatory Toxicology

Toxicology & Human Exposure

The toxicological relevance of an agrochemical is one of the considerations during the evaluation process leading to the registration of a pesticide. A series of studies and assessments is performed in order to meet requirements in the areas of, among others, acute and chronic toxicity, genotoxicity, carcinogenicity, reproductive toxicity, neurotoxicity and toxicokinetics.

Human Exposure

Estimating the degree of exposure of people applying pesticides (operators), as well as of those who subsequently carry out necessary work in the treated crop (workers), is a key aspect of the evaluation of agrochemicals. The assessment also includes people who might be affected because they are passing by the field at the time of pesticide application (bystanders), and those who live in the vicinity of treated fields (residents). The first step in risk analysis for these groups of people involves the use of authority-approved models. If necessary, the calculations are then refined using experimental data in order to demonstrate that safe use is possible.

Our services

  • Data gap analysis
  • Analysis and evaluation of the available toxicology data
  • Analysis and evaluation of use scenarios and available data
  • Study management and monitoring of exposure studies
  • Report writing and preparation of the respective Dossier Section
  • Development of registration strategies